Films with any kind of illness
by notaprincess9 | created - 02 Jan 2017 | updated - 20 Mar 2023 | PublicIncludes: Mental Illnesses, disabilities, birth defects or other acquired medical conditions, types of paraphilia, types of addiction. WILL not include a ton of films because almost every crime/horror film depicts a psychopath or sociopath. I will include a film if the disorder plays a huge role in the film's plot or unraveling.
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1. 50/50 (2011)
R | 100 min | Comedy, Drama, Romance
Inspired by a true story, a comedy centered on a 27-year-old guy who learns of his cancer diagnosis and his subsequent struggle to beat the disease.
Director: Jonathan Levine | Stars: Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard
Votes: 343,011 | Gross: $35.01M
Cancer (schwannoma neurofibrosarcoma)
2. You're Not You (2014)
R | 102 min | Drama
A drama centered on a classical pianist who has been diagnosed with ALS and the brash college student who becomes her caregiver.
Director: George C. Wolfe | Stars: Hilary Swank, Emmy Rossum, Josh Duhamel, Stephanie Beatriz
Votes: 26,840
Amyotrophic lateral sclerosis
3. The Intouchables (2011)
R | 112 min | Comedy, Drama
After he becomes a quadriplegic from a paragliding accident, an aristocrat hires a young man from the projects to be his caregiver.
Directors: Olivier Nakache, Éric Toledano | Stars: François Cluzet, Omar Sy, Anne Le Ny, Audrey Fleurot
Votes: 930,380 | Gross: $13.18M
Tetralegia
4. Bleed for This (2016)
R | 117 min | Biography, Drama, Sport
The inspirational story of World Champion Boxer Vinny Pazienza who, after a near fatal car crash which left him not knowing if he'd ever walk again, made one of sports' most incredible comebacks.
Director: Ben Younger | Stars: Miles Teller, Aaron Eckhart, Katey Sagal, Ciarán Hinds
Votes: 30,298 | Gross: $4.85M
5. Miss You Already (2015)
PG-13 | 112 min | Comedy, Drama, Romance
The friendship between two life-long girlfriends is put to the test when one starts a family and the other falls ill.
Director: Catherine Hardwicke | Stars: Drew Barrymore, Toni Collette, Dominic Cooper, Paddy Considine
Votes: 19,890 | Gross: $1.16M
Breast cancer
6. My Sister's Keeper (2009)
PG-13 | 109 min | Drama, Family
Anna Fitzgerald looks to earn medical emancipation from her parents who until now have relied on their youngest child to help their leukemia-stricken daughter Kate remain alive.
Director: Nick Cassavetes | Stars: Cameron Diaz, Abigail Breslin, Alec Baldwin, Walter Raney
Votes: 98,383 | Gross: $49.20M
Cancer (Acute promyelocytic leukemia)
7. Million Dollar Baby (2004)
PG-13 | 132 min | Drama, Sport
Frankie, an ill-tempered old coach, reluctantly agrees to train aspiring boxer Maggie. Impressed with her determination and talent, he helps her become the best and the two soon form a close bond.
Director: Clint Eastwood | Stars: Hilary Swank, Clint Eastwood, Morgan Freeman, Jay Baruchel
Votes: 722,226 | Gross: $100.49M
Tetraplegia
8. Still Alice (2014)
PG-13 | 101 min | Drama
A linguistics professor and her family find their bonds tested when she is diagnosed with Alzheimer's Disease.
Directors: Richard Glatzer, Wash Westmoreland | Stars: Julianne Moore, Alec Baldwin, Kristen Stewart, Kate Bosworth
Votes: 143,549 | Gross: $18.75M
Altzheimer's Disease
9. Rain Man (1988)
R | 133 min | Drama
After a selfish L.A. yuppie learns his estranged father left a fortune to an autistic-savant brother in Ohio that he didn't know existed, he absconds with his brother and sets out across the country, hoping to gain a larger inheritance.
Director: Barry Levinson | Stars: Dustin Hoffman, Tom Cruise, Valeria Golino, Gerald R. Molen
Votes: 546,967 | Gross: $178.80M
Autism Spectrum Disorder & Obsessive Compulsive Disorder (OCD)
10. A Beautiful Mind (2001)
PG-13 | 135 min | Biography, Drama, Mystery
A mathematical genius, John Nash made an astonishing discovery early in his career and stood on the brink of international acclaim. But the handsome and arrogant Nash soon found himself on a harrowing journey of self-discovery.
Director: Ron Howard | Stars: Russell Crowe, Ed Harris, Jennifer Connelly, Christopher Plummer
Votes: 987,712 | Gross: $170.74M
Paranoid Schizophrenia
11. The Theory of Everything (2014)
PG-13 | 123 min | Biography, Drama, Romance
Stephen Hawking gets unprecedented success in the field of physics despite being diagnosed with motor neuron disease at the age of 21. He defeats awful odds as his first wife Jane aids him loyally.
Director: James Marsh | Stars: Eddie Redmayne, Felicity Jones, Tom Prior, Sophie Perry
Votes: 482,409 | Gross: $35.89M
Motor Neurone Disease
12. Me and Earl and the Dying Girl (2015)
PG-13 | 105 min | Comedy, Drama, Romance
High schooler Greg, who spends most of his time making parodies of classic movies with his co-worker Earl, finds his outlook forever altered after befriending a classmate who has just been diagnosed with cancer.
Director: Alfonso Gomez-Rejon | Stars: Thomas Mann, RJ Cyler, Olivia Cooke, Nick Offerman
Votes: 138,372 | Gross: $6.74M
Cancer (Leukemia)
13. Now Is Good (2012)
PG-13 | 103 min | Drama, Romance
A teenage girl dying of leukemia compiles a list of things she would like to do before passing away. Topping the list is her desire to lose her virginity.
Director: Ol Parker | Stars: Dakota Fanning, Josef Altin, Jeremy Irvine, Paddy Considine
Votes: 35,044
Cancer (Acute lymphoblastic leukemia)
14. Girl, Interrupted (1999)
R | 127 min | Biography, Drama
A directionless teenager, Susanna, is rushed to Claymoore, a mental institution, after a supposed suicide attempt. There, she befriends a group of troubled women who deeply influence her life.
Director: James Mangold | Stars: Winona Ryder, Angelina Jolie, Clea DuVall, Brittany Murphy
Votes: 211,537 | Gross: $28.87M
Anti-social personality disorder/Borderline personality disorder
15. Melancholia (2011)
R | 135 min | Drama, Sci-Fi
Two sisters find their already strained relationship challenged as a mysterious new planet threatens to collide with Earth.
Director: Lars von Trier | Stars: Kirsten Dunst, Charlotte Gainsbourg, Kiefer Sutherland, Alexander Skarsgård
Votes: 196,048 | Gross: $3.03M
Clinical Depression
16. Black Swan (2010)
R | 108 min | Drama, Thriller
Nina is a talented but unstable ballerina on the verge of stardom. Pushed to the breaking point by her artistic director and a seductive rival, Nina's grip on reality slips, plunging her into a waking nightmare.
Director: Darren Aronofsky | Stars: Natalie Portman, Mila Kunis, Vincent Cassel, Winona Ryder
Votes: 825,450 | Gross: $106.95M
Schizophrenia
17. The Machinist (2004)
R | 101 min | Drama, Thriller
An industrial worker who hasn't slept in a year begins to doubt his own sanity.
Director: Brad Anderson | Stars: Christian Bale, Jennifer Jason Leigh, Aitana Sánchez-Gijón, John Sharian
Votes: 415,810 | Gross: $1.08M
Insomnia and some sort of amnesia
18. What's Eating Gilbert Grape (1993)
PG-13 | 118 min | Drama
A young man in a small Midwestern town struggles to care for his mentally-disabled younger brother and morbidly obese mother while attempting to pursue his own happiness.
Director: Lasse Hallström | Stars: Johnny Depp, Leonardo DiCaprio, Juliette Lewis, Mary Steenburgen
Votes: 254,237 | Gross: $9.17M
Autism Spectrum Disorder
19. Silver Linings Playbook (2012)
R | 122 min | Comedy, Drama, Romance
After a stint in a mental institution, former teacher Pat Solitano moves back in with his parents and tries to reconcile with his ex-wife. Things get more challenging when Pat meets Tiffany, a mysterious girl with problems of her own.
Director: David O. Russell | Stars: Bradley Cooper, Jennifer Lawrence, Robert De Niro, Jacki Weaver
Votes: 743,135 | Gross: $132.09M
Bipolar disorder
20. Fight Club (1999)
R | 139 min | Drama
An insomniac office worker and a devil-may-care soap maker form an underground fight club that evolves into much more.
Director: David Fincher | Stars: Brad Pitt, Edward Norton, Meat Loaf, Zach Grenier
Votes: 2,326,274 | Gross: $37.03M
Dissociative Personality Disorder (Multiple personality disorder)
21. Wristcutters: A Love Story (2006)
R | 88 min | Comedy, Drama, Fantasy
A film set in a strange afterlife way station that has been reserved for people who have committed suicide.
Director: Goran Dukic | Stars: Patrick Fugit, Shea Whigham, Tom Waits, Will Arnett
Votes: 57,732 | Gross: $0.32M
Clinical depression
22. Lars and the Real Girl (2007)
PG-13 | 106 min | Comedy, Drama, Romance
A delusional young man strikes up an unconventional relationship with a doll he finds on the Internet.
Director: Craig Gillespie | Stars: Ryan Gosling, Emily Mortimer, Paul Schneider, R.D. Reid
Votes: 155,517 | Gross: $5.97M
Delusional psychotic disorder
23. The Number 23 (2007)
R | 98 min | Crime, Mystery, Thriller
Walter Sparrow becomes obsessed with a novel that he believes was written about him, as more and more similarities between himself and his literary alter ego seem to arise.
Director: Joel Schumacher | Stars: Jim Carrey, Virginia Madsen, Logan Lerman, Danny Huston
Votes: 212,717 | Gross: $35.19M
Dissociative Personality Disorder (Multiple personality disorder)
24. Robot & Frank (2012)
PG-13 | 89 min | Comedy, Crime, Drama
In the near future, an ex-jewel thief receives a gift from his son: a robot butler programmed to look after him. But soon the two companions try their luck as a heist team.
Director: Jake Schreier | Stars: Peter Sarsgaard, Frank Langella, Susan Sarandon, Liv Tyler
Votes: 65,786 | Gross: $3.33M
Dementia
25. It's Kind of a Funny Story (2010)
PG-13 | 101 min | Comedy, Drama, Romance
A clinically-depressed teenager gets a new start after he checks himself into an adult psychiatric ward.
Directors: Anna Boden, Ryan Fleck | Stars: Keir Gilchrist, Zach Galifianakis, Emma Roberts, Dana DeVestern
Votes: 148,277 | Gross: $6.35M
Clinical depression/suicidal tendencies
26. The Virgin Suicides (1999)
R | 97 min | Drama, Romance
A group of male friends become obsessed with five mysterious sisters who are sheltered by their strict, religious parents in suburban Detroit in the mid 1970s.
Director: Sofia Coppola | Stars: Kirsten Dunst, Josh Hartnett, James Woods, Kathleen Turner
Votes: 169,367 | Gross: $4.86M
Clinical depression/suicidal tendencies
27. The Perks of Being a Wallflower (2012)
PG-13 | 103 min | Drama
Charlie, a 15-year-old introvert, enters high school and is nervous about his new life. When he befriends his seniors, he learns to cope with his friend's suicide and his tumultuous past.
Director: Stephen Chbosky | Stars: Logan Lerman, Emma Watson, Ezra Miller, Paul Rudd
Votes: 548,398 | Gross: $17.74M
Clinical depression/suicidal tendencies
28. Split (IX) (2016)
PG-13 | 117 min | Horror, Thriller
Three girls are kidnapped by a man with a diagnosed 23 distinct personalities. They must try to escape before the apparent emergence of a frightful new 24th.
Director: M. Night Shyamalan | Stars: James McAvoy, Anya Taylor-Joy, Haley Lu Richardson, Jessica Sula
Votes: 554,923 | Gross: $138.29M
Dissociative Identity Disorder (Multiple personality disorder)
29. Goodnight Mommy (2014)
R | 99 min | Horror, Mystery, Thriller
Twin boys move to a new house with their mother after she has face-changing cosmetic surgery, but under the bandages is someone the boys don't recognize.
Directors: Severin Fiala, Veronika Franz | Stars: Lukas Schwarz, Elias Schwarz, Susanne Wuest, Hans Escher
Votes: 59,820 | Gross: $1.17M
Complicated frief (Persisent complex bereavement disorder)
30. Session 9 (2001)
R | 97 min | Drama, Horror, Mystery
Tensions rise within an asbestos cleaning crew as they work in an abandoned mental hospital with a horrific past that seems to be coming back.
Director: Brad Anderson | Stars: David Caruso, Stephen Gevedon, Paul Guilfoyle, Josh Lucas
Votes: 62,937 | Gross: $0.38M
Dissociative Idenity Disorder (Multiple personality disorder)
31. The Fault in Our Stars (2014)
PG-13 | 126 min | Drama, Romance
Hazel and Gus are teenagers who meet at a cancer support group and fall in love. They both share the same acerbic wit and a love of books, especially "An Imperial Affliction", so they embark on a journey to visit an author in Amsterdam.
Director: Josh Boone | Stars: Shailene Woodley, Ansel Elgort, Nat Wolff, Laura Dern
Votes: 401,336 | Gross: $124.87M
Thyroid cancer & Bone cancer
32. The Railway Man (2013)
R | 116 min | Biography, Drama, Romance
A former British Army officer, who was tortured as a prisoner of war at a Japanese labor camp during World War II, discovers that the man responsible for much of his treatment is still alive and sets out to confront him.
Director: Jonathan Teplitzky | Stars: Colin Firth, Nicole Kidman, Stellan Skarsgård, Jeremy Irvine
Votes: 42,669 | Gross: $4.44M
Post traumatic stress disorder (PTSD)
33. Brothers (I) (2009)
R | 105 min | Drama, Thriller, War
While on tour in Afghanistan, Sam's helicopter is shot down and he is presumed dead. Back home, it is his screw-up brother who looks after the family. Sam does return, but with a lot of excess baggage.
Director: Jim Sheridan | Stars: Jake Gyllenhaal, Natalie Portman, Tobey Maguire, Sam Shepard
Votes: 147,005 | Gross: $28.50M
Post traumatic stress disorder (PTSD)
34. Sylvia (2003)
R | 100 min | Biography, Drama, Romance
Story of the relationship between poets Edward James "Ted" Hughes and Sylvia Plath.
Director: Christine Jeffs | Stars: Gwyneth Paltrow, Daniel Craig, Lucy Davenport, David Birkin
Votes: 11,268 | Gross: $1.30M
Clinical Depression
35. The Royal Tenenbaums (2001)
R | 110 min | Comedy, Drama
The eccentric members of a dysfunctional family reluctantly gather under the same roof for various reasons.
Director: Wes Anderson | Stars: Gene Hackman, Gwyneth Paltrow, Anjelica Huston, Ben Stiller
Votes: 313,368 | Gross: $52.36M
Clinical Depression
36. A Single Man (2009)
R | 99 min | Crime, Drama, Romance
An English professor, one year after the sudden death of his boyfriend, is unable to cope with his typical days in 1960s Los Angeles.
Director: Tom Ford | Stars: Colin Firth, Julianne Moore, Matthew Goode, Nicholas Hoult
Votes: 117,803 | Gross: $9.17M
Clinical Depression
37. Little Miss Sunshine (2006)
R | 101 min | Comedy, Drama
A family determined to get their young daughter into the finals of a beauty pageant take a cross-country trip in their VW bus.
Directors: Jonathan Dayton, Valerie Faris | Stars: Steve Carell, Toni Collette, Greg Kinnear, Abigail Breslin
Votes: 518,455 | Gross: $59.89M
Clinical Depression
38. Cake (II) (2014)
R | 102 min | Drama
The acerbic, hilarious Claire Bennett becomes fascinated by the suicide of a woman in her chronic pain support group. As she uncovers the details of Nina's suicide and develops a poignant relationship with Nina's husband, she also grapples with her own, very raw personal tragedy.
Director: Daniel Barnz | Stars: Jennifer Aniston, Adriana Barraza, Anna Kendrick, Sam Worthington
Votes: 38,891 | Gross: $1.87M
Clinical Depression &Chronic Pain
39. The Diving Bell and the Butterfly (2007)
PG-13 | 112 min | Biography, Drama
The true story of Elle editor Jean-Dominique Bauby who suffers a stroke and has to live with an almost totally paralyzed body; only his left eye isn't paralyzed.
Director: Julian Schnabel | Stars: Mathieu Amalric, Emmanuelle Seigner, Marie-Josée Croze, Anne Consigny
Votes: 110,457 | Gross: $5.99M
Locked-In Syndrome (Paralysis)
40. Love & Other Drugs (2010)
R | 112 min | Comedy, Drama, Romance
In 1990s Pittsburgh, a medicine peddler starts a relationship with a young woman suffering from Parkinson's disease.
Director: Edward Zwick | Stars: Jake Gyllenhaal, Anne Hathaway, Judy Greer, Oliver Platt
Votes: 224,399 | Gross: $32.37M
Parkinson's Disease
41. Thanks for Sharing (2012)
R | 112 min | Comedy, Drama, Romance
A romantic comedy that brings together three disparate characters who are learning to face a challenging and often confusing world as they struggle together against a common demon: sex addiction.
Director: Stuart Blumberg | Stars: Mark Ruffalo, Tim Robbins, Gwyneth Paltrow, Josh Gad
Votes: 29,543 | Gross: $1.06M
Sexual addiction (Hypersexuality)
42. Rachel Getting Married (2008)
R | 113 min | Drama, Romance
A young woman who has been in and out of rehab for the past ten years returns home for the weekend for her sister's wedding.
Director: Jonathan Demme | Stars: Anne Hathaway, Rosemarie DeWitt, Debra Winger, Sebastian Stan
Votes: 51,276 | Gross: $12.80M
Drug addiction
43. Nymphomaniac: Vol. I (2013)
Not Rated | 117 min | Drama
A self-diagnosed nymphomaniac recounts her erotic experiences to the man who saved her after a beating.
Director: Lars von Trier | Stars: Charlotte Gainsbourg, Stellan Skarsgård, Stacy Martin, Shia LaBeouf
Votes: 131,608 | Gross: $0.79M
Sexual addiction (Nymphomania)
44. Nymphomaniac: Vol. II (2013)
Not Rated | 124 min | Drama
The continuation of Joe's sexually dictated life delves into the darker aspects of her adulthood, obsessions and what led to her being in Seligman's care.
Director: Lars von Trier | Stars: Charlotte Gainsbourg, Stellan Skarsgård, Willem Dafoe, Jamie Bell
Votes: 98,226 | Gross: $0.33M
Sexual addiction (Nymphomania)
45. The Woodsman (2004)
R | 87 min | Drama
A child molester returns to his hometown after 12 years in prison and attempts to start a new life.
Director: Nicole Kassell | Stars: Kevin Bacon, Kyra Sedgwick, Yasiin Bey, David Alan Grier
Votes: 35,400 | Gross: $0.04M
Pedophilia
46. As Good as It Gets (1997)
PG-13 | 139 min | Comedy, Drama, Romance
A single mother and waitress, a misanthropic author, and a gay artist form an unlikely friendship after the artist is assaulted in a robbery.
Director: James L. Brooks | Stars: Jack Nicholson, Helen Hunt, Greg Kinnear, Cuba Gooding Jr.
Votes: 318,645 | Gross: $148.48M
Obsessive Compulsive Disorder (OCD)
47. Little Children (2006)
R | 137 min | Drama, Romance
The lives of two lovelorn spouses from separate marriages, a registered sex offender, and a disgraced ex-police officer intersect as they struggle to resist their vulnerabilities and temptations in suburban Massachusetts.
Director: Todd Field | Stars: Kate Winslet, Jennifer Connelly, Patrick Wilson, Jackie Earle Haley
Votes: 116,814 | Gross: $5.46M
Pedophilia
48. Forrest Gump (1994)
PG-13 | 142 min | Drama, Romance
The history of the United States from the 1950s to the '70s unfolds from the perspective of an Alabama man with an IQ of 75, who yearns to be reunited with his childhood sweetheart.
Director: Robert Zemeckis | Stars: Tom Hanks, Robin Wright, Gary Sinise, Sally Field
Votes: 2,259,298 | Gross: $330.25M
Borderline Intellectual Disability
49. Rust and Bone (2012)
R | 120 min | Drama, Romance
Put in charge of his young son, Alain leaves Belgium for Antibes to live with his sister and her husband as a family. Alain's bond with Stephanie, a killer whale trainer, grows deeper after Stephanie suffers a horrible accident.
Director: Jacques Audiard | Stars: Marion Cotillard, Matthias Schoenaerts, Armand Verdure, Céline Sallette
Votes: 70,326 | Gross: $2.06M
Double amputtee
50. I Am Sam (2001)
PG-13 | 132 min | Drama
An intellectually disabled man fights for custody of his 7-year-old daughter and in the process teaches his cold-hearted lawyer the value of love and family.
Director: Jessie Nelson | Stars: Sean Penn, Michelle Pfeiffer, Dakota Fanning, Dianne Wiest
Votes: 155,378 | Gross: $40.31M
Developmental Disability
51. 50 First Dates (2004)
PG-13 | 99 min | Comedy, Drama, Romance
Henry Roth is a man afraid of commitment until he meets the beautiful Lucy. They hit it off and Henry think he's finally found the girl of his dreams until discovering she has short-term memory loss and forgets him the next day.
Director: Peter Segal | Stars: Adam Sandler, Drew Barrymore, Rob Schneider, Sean Astin
Votes: 382,529 | Gross: $120.91M
Anterograde amnesia
52. The Vow (2012)
PG-13 | 104 min | Drama, Romance
A car accident puts Paige in a coma, and when she wakes up with severe memory loss, her husband Leo works to win her heart again.
Director: Michael Sucsy | Stars: Rachel McAdams, Channing Tatum, Sam Neill, Jessica Lange
Votes: 205,077 | Gross: $125.01M
Retrograde amnesia
53. The Music Never Stopped (2011)
PG | 105 min | Drama, Music
Tale of a father who struggles to bond with his estranged son Gabriel, after Gabriel suffers from a brain tumor that prevents him from forming new memories. With Gabriel unable to shed the ... See full summary »
Director: Jim Kohlberg | Stars: Lou Taylor Pucci, J.K. Simmons, Julia Ormond, Cara Seymour
Votes: 8,691 | Gross: $0.26M
Brain tumor
54. Scent of a Woman (1992)
R | 156 min | Drama
A prep school student needing money agrees to "babysit" a blind man, but the job is not at all what he anticipated.
Director: Martin Brest | Stars: Al Pacino, Chris O'Donnell, James Rebhorn, Gabrielle Anwar
Votes: 329,218 | Gross: $63.90M
Blindness
55. Suicide Room (2011)
Not Rated | 110 min | Crime, Drama, Thriller
After suffering extreme humiliation at school, Dominik holes himself up in his room and begins spending all his time in a virtual reality chat room.
Director: Jan Komasa | Stars: Jakub Gierszal, Roma Gasiorowska, Agata Kulesza, Christoph Pieczynski
Votes: 11,568
Clinical Depression
56. The Notebook (2004)
PG-13 | 123 min | Drama, Romance
An elderly man reads to a woman with dementia the story of two young lovers whose romance is threatened by the difference in their respective social classes.
Director: Nick Cassavetes | Stars: Gena Rowlands, James Garner, Rachel McAdams, Ryan Gosling
Votes: 620,801 | Gross: $81.00M
Dementia
57. A Walk to Remember (2002)
PG | 101 min | Drama, Romance
Two North Carolina teens, Landon Carter and Jamie Sullivan, are thrown together after Landon gets into trouble and is sentenced to perform community service.
Director: Adam Shankman | Stars: Mandy Moore, Shane West, Peter Coyote, Daryl Hannah
Votes: 221,461 | Gross: $41.28M
Cancer (Leukemia)
58. When a Man Loves a Woman (1994)
R | 126 min | Drama, Romance
The seemingly perfect relationship between a man and his wife is tested as a result of her alcoholism.
Director: Luis Mandoki | Stars: Meg Ryan, Andy Garcia, Ellen Burstyn, Tina Majorino
Votes: 23,587 | Gross: $50.02M
Alchoholism
59. Leaving Las Vegas (1995)
R | 111 min | Drama, Romance
Ben Sanderson, a Hollywood screenwriter who lost everything because of his alcoholism, arrives in Las Vegas to drink himself to death. There, he meets and forms an uneasy friendship and non-interference pact with prostitute Sera.
Director: Mike Figgis | Stars: Nicolas Cage, Elisabeth Shue, Julian Sands, Richard Lewis
Votes: 134,764 | Gross: $32.03M
Alcoholism
60. Requiem for a Dream (2000)
R | 102 min | Drama
The drug-induced utopias of four Coney Island people are shattered when their addictions run deep..
Director: Darren Aronofsky | Stars: Ellen Burstyn, Jared Leto, Jennifer Connelly, Marlon Wayans
Votes: 899,396 | Gross: $3.64M
Drug abuse/addiction
61. Donnie Darko (2001)
R | 113 min | Drama, Mystery, Sci-Fi
After narrowly escaping a bizarre accident, a troubled teenager is plagued by visions of a man in a large rabbit suit who manipulates him to commit a series of crimes.
Director: Richard Kelly | Stars: Jake Gyllenhaal, Jena Malone, Mary McDonnell, Holmes Osborne
Votes: 850,578 | Gross: $1.48M
Schizophrenia
62. I Smile Back (2015)
R | 85 min | Drama, Mystery, Romance
Addicted to drugs and alcohol, a housewife's self-destructive behavior starts to take its toll on her husband and two young children.
Director: Adam Salky | Stars: Sarah Silverman, Josh Charles, Skylar Gaertner, Shayne Coleman
Votes: 5,709 | Gross: $0.06M
Clinical depression/anxiety
63. Before I Go to Sleep (2014)
R | 92 min | Drama, Mystery, Thriller
A woman wakes up every day, remembering nothing as a result of a traumatic accident in her past. One day, new terrifying truths emerge that force her to question everyone around her.
Director: Rowan Joffe | Stars: Nicole Kidman, Colin Firth, Mark Strong, Anne-Marie Duff
Votes: 84,188 | Gross: $2.96M
Anterograde Amnesia
64. Fatal Attraction (1987)
R | 119 min | Drama, Thriller
A married man's one-night stand comes back to haunt him when that lover begins to stalk him and his family.
Director: Adrian Lyne | Stars: Michael Douglas, Glenn Close, Anne Archer, Ellen Latzen
Votes: 97,210 | Gross: $156.65M
Clérambault's Syndrome (Erotomania)
65. The Skeleton Twins (2014)
R | 93 min | Comedy, Drama, Romance
Having both coincidentally cheated death on the same day, estranged twins reunite with the possibility of mending their relationship.
Director: Craig Johnson | Stars: Kristen Wiig, Bill Hader, Luke Wilson, Ty Burrell
Votes: 44,881 | Gross: $5.28M
Clinical Depression/Suicidal thoughts
66. Nine Dead (2009)
R | 86 min | Crime, Drama, Horror
Nine strangers are kidnapped and forced to figure out the connection they have to each other as one has to die every ten minutes.
Director: Chris Shadley | Stars: Melissa Joan Hart, William Lee Scott, John Terry, James C. Victor
Votes: 14,275
Pedophilia (Paraphilia)
67. Mystic River (2003)
R | 138 min | Crime, Drama, Mystery
The tragic murder of a 19-year-old girl reunites three childhood friends still living in Boston--the victim's gangster father, a detective, and the disturbed man they both suspect of killing her.
Director: Clint Eastwood | Stars: Sean Penn, Tim Robbins, Kevin Bacon, Emmy Rossum
Votes: 486,107 | Gross: $90.14M
PTSD (Post-traumatic Stress Disorder)
68. Keane (2004)
R | 100 min | Drama, Mystery, Thriller
A disheveled man desperately searches New York City for his young daughter.
Director: Lodge Kerrigan | Stars: Damian Lewis, Liza Colón-Zayas, John Tormey, Brenda Denmark
Votes: 5,820 | Gross: $0.03M
Schizophrenia
69. Filth (I) (2013)
R | 97 min | Action, Comedy, Crime
A corrupt, junkie cop with bipolar disorder attempts to manipulate his way through a promotion in order to win back his wife and daughter while also fighting his own inner demons.
Director: Jon S. Baird | Stars: James McAvoy, Jamie Bell, Eddie Marsan, Imogen Poots
Votes: 115,892 | Gross: $0.03M
Borderline Personality Disorder
70. Half Nelson (2006)
R | 106 min | Drama
An inner-city junior high school teacher with a drug habit forms an unlikely friendship with one of his students after she discovers his secret.
Director: Ryan Fleck | Stars: Ryan Gosling, Anthony Mackie, Shareeka Epps, Jeff Lima
Votes: 92,002 | Gross: $2.69M
Drug addiction
71. Walk the Line (2005)
PG-13 | 136 min | Biography, Drama, Music
A chronicle of country music legend Johnny Cash's life, from his early days on an Arkansas cotton farm to his rise to fame with Sun Records in Memphis, where he recorded alongside Elvis Presley, Jerry Lee Lewis, and Carl Perkins.
Director: James Mangold | Stars: Joaquin Phoenix, Reese Witherspoon, Ginnifer Goodwin, Robert Patrick
Votes: 265,991 | Gross: $119.52M
Alcoholism
72. Seven Pounds (2008)
PG-13 | 123 min | Drama, Mystery, Thriller
A man with a fateful secret embarks on an extraordinary journey of redemption by forever changing the lives of seven strangers.
Director: Gabriele Muccino | Stars: Will Smith, Rosario Dawson, Woody Harrelson, Michael Ealy
Votes: 315,324 | Gross: $69.95M
PTSD & congenital heart condition
73. Autumn in New York (2000)
PG-13 | 103 min | Drama, Romance
Romantic drama about an aging playboy who falls for a sweet, but terminally ill, young woman.
Director: Joan Chen | Stars: Richard Gere, Winona Ryder, Anthony LaPaglia, Elaine Stritch
Votes: 28,313 | Gross: $37.75M
Neuroblastoma
74. Lorenzo's Oil (1992)
PG-13 | 129 min | Biography, Drama
Lorenzo Odone, a Virginia 5-year-old, develops a degenerative nerve disease so rare that nobody is working on a cure, so his parents decide to immerse themselves in research and tackle the problem themselves.
Director: George Miller | Stars: Nick Nolte, Susan Sarandon, Peter Ustinov, Kathleen Wilhoite
Votes: 24,050 | Gross: $7.29M
Adrenoleukodystrophy (ALD)
75. Dying Young (1991)
R | 111 min | Drama, Romance
A caregiver falls in love with a terminally ill man.
Director: Joel Schumacher | Stars: Julia Roberts, Campbell Scott, Vincent D'Onofrio, Colleen Dewhurst
Votes: 17,217 | Gross: $33.67M
Leukemia
76. Love Story (1970)
PG | 100 min | Drama, Romance
A boy and a girl from different backgrounds fall in love regardless of their upbringing - and then tragedy strikes.
Director: Arthur Hiller | Stars: Ali MacGraw, Ryan O'Neal, John Marley, Ray Milland
Votes: 37,466 | Gross: $106.40M
Leukemia
77. A Moment to Remember (2004)
PG-13 | 117 min | Drama, Romance
A young couple's enduring love is tested when 27-year-old Su-jin is diagnosed with a rare form of Alzheimer's disease.
Directors: Park Kyung-Jin, John H. Lee, Kim Tae-Won | Stars: Jung Woo-sung, Son Ye-jin, Jong-hak Baek, Lee Seon-jin
Votes: 25,582
Alzheimer's disease
78. By the Sea (2015)
R | 122 min | Drama, Romance
A couple tries to repair their marriage while staying at a hotel in France.
Director: Angelina Jolie | Stars: Brad Pitt, Angelina Jolie, Mélanie Laurent, Melvil Poupaud
Votes: 22,563 | Gross: $0.53M
Depression
79. The Ultimate Gift (2006)
PG | 114 min | Drama, Family, Romance
A deceased billionaire leaves his spoiled adult grandson a series of odd tasks to perform in order to receive "the ultimate gift," with the resentful grandson having no idea what that might be.
Director: Michael O. Sajbel | Stars: Drew Fuller, James Garner, Abigail Breslin, Bill Cobbs
Votes: 20,448 | Gross: $3.44M
Leukemia
80. Heathers (1988)
R | 103 min | Comedy, Crime
At Westerburg High where cliques rule, jocks dominate and all the popular girls are named Heather, it's going to take a Veronica and mysterious new kid to give teen angst a body count.
Director: Michael Lehmann | Stars: Winona Ryder, Christian Slater, Shannen Doherty, Lisanne Falk
Votes: 115,976 | Gross: $1.11M
Sociopathy
81. Freeheld (2015)
PG-13 | 103 min | Biography, Drama, Romance
New Jersey police lieutenant Laurel Hester and her registered domestic partner Stacie Andree battle to secure Hester's pension benefits when she is diagnosed with terminal cancer.
Director: Peter Sollett | Stars: Julianne Moore, Elliot Page, Steve Carell, Michael Shannon
Votes: 13,243 | Gross: $0.53M
Terminal lung cancer
82. The Fountain (2006)
PG-13 | 97 min | Drama, Mystery, Romance
As a modern-day scientist, Tommy is struggling with mortality, desperately searching for the medical breakthrough that will save the life of his cancer-stricken wife, Izzi.
Director: Darren Aronofsky | Stars: Hugh Jackman, Rachel Weisz, Sean Patrick Thomas, Ellen Burstyn
Votes: 248,854 | Gross: $10.14M
Cancer
83. Everything, Everything (2017)
PG-13 | 96 min | Drama, Romance
A teenager who's spent her whole life confined to her home falls for the boy next door.
Director: Stella Meghie | Stars: Amandla Stenberg, Nick Robinson, Anika Noni Rose, Ana de la Reguera
Votes: 42,502 | Gross: $34.00M
SCID
84. The Other Sister (1999)
PG-13 | 129 min | Comedy, Drama, Romance
A mentally challenged young woman seeks independence by obtaining her own apartment and attending college while her family plans her sister's wedding.
Director: Garry Marshall | Stars: Juliette Lewis, Diane Keaton, Giovanni Ribisi, Tom Skerritt
Votes: 13,069 | Gross: $27.80M
Mild Intellectual Disabilty
85. Song One (2014)
PG-13 | 86 min | Drama, Music, Romance
A young woman strikes up a relationship with her ailing brother's favorite musician.
Director: Kate Barker-Froyland | Stars: Anne Hathaway, Johnny Flynn, Ben Rosenfield, Faiza Mouha Abbazi
Votes: 10,279 | Gross: $0.03M
Coma
86. The Big Sick (2017)
R | 120 min | Comedy, Drama, Romance
Pakistan-born comedian Kumail Nanjiani and grad student Emily Gardner fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family's expectations, and his true feelings.
Director: Michael Showalter | Stars: Kumail Nanjiani, Zoe Kazan, Holly Hunter, Ray Romano
Votes: 143,658 | Gross: $42.87M
Coma
87. To the Bone (I) (2017)
TV-MA | 107 min | Drama
A young woman, dealing with anorexia, meets an unconventional doctor who challenges her to face her condition and embrace life.
Director: Marti Noxon | Stars: Rebekah Kennedy, Lily Collins, Dana L. Wilson, Ziah Colon
Votes: 54,896
Anorexia
88. Stronger (I) (2017)
R | 119 min | Biography, Drama
Stronger is the inspiring real life story of Jeff Bauman, an ordinary man who captured the hearts of his city and the world to become a symbol of hope after surviving the 2013 Boston Marathon bombing.
Director: David Gordon Green | Stars: Jake Gyllenhaal, Tatiana Maslany, Miranda Richardson, Richard Lane Jr.
Votes: 49,696 | Gross: $4.21M
Double amputee
89. Breathe (I) (2017)
PG-13 | 118 min | Biography, Drama, Romance
The inspiring true love story of Robin and Diana Cavendish, an adventurous couple who refuse to give up in the face of a devastating disease.
Director: Andy Serkis | Stars: Andrew Garfield, Claire Foy, Hugh Bonneville, Ed Speleers
Votes: 24,695 | Gross: $0.49M
Quadriplegia
90. Mozart and the Whale (2005)
PG-13 | 94 min | Comedy, Drama, Romance
A love story between two savants with Asperger's syndrome, a kind of autism, whose conditions sabotage their budding relationship.
Director: Petter Næss | Stars: Josh Hartnett, Radha Mitchell, Gary Cole, Sheila Kelley
Votes: 9,297 | Gross: $0.04M
Asperger's syndrome
91. The House of Yes (1997)
R | 85 min | Comedy, Drama, Thriller
A mentally unbalanced young woman - who is convinced she is Jackie Kennedy - flies into a murderous rage when her brother returns home to reveal he is engaged.
Director: Mark Waters | Stars: Parker Posey, Josh Hamilton, Tori Spelling, Freddie Prinze Jr.
Votes: 8,836 | Gross: $0.62M
92. Me Before You (2016)
PG-13 | 110 min | Drama, Romance
A girl in a small town forms an unlikely bond with a recently-paralyzed man she's taking care of.
Director: Thea Sharrock | Stars: Emilia Clarke, Sam Claflin, Janet McTeer, Charles Dance
Votes: 287,479 | Gross: $56.25M
Paralysis
93. Oasis (2002)
133 min | Drama, Romance
An irresponsible and childish ex-con befriends a girl with cerebral palsy and develops a progressively stronger bond with her.
Director: Lee Chang-dong | Stars: Sol Kyung-gu, Moon So-ri, Ahn Nae-sang, Ryu Seung-wan
Votes: 10,411
cerebral palsy
94. 100 Meters (2016)
108 min | Biography, Comedy, Drama
Based on true events, a Spanish man with multiple sclerosis who tried to finish an Iron-Man competition despite he was told that he could not make 100 meters.
Director: Marcel Barrena | Stars: Dani Rovira, Karra Elejalde, Alexandra Jiménez, David Verdaguer
Votes: 6,955
multiple sclerosis
95. Time to Leave (2005)
Unrated | 81 min | Drama
A fashion photographer with terminal cancer elects to die alone, preparing others to live past him rather than prolong the inevitable with chemotherapy or be smothered in sympathy by those who know him.
Director: François Ozon | Stars: Melvil Poupaud, Jeanne Moreau, Valeria Bruni Tedeschi, Daniel Duval
Votes: 9,263 | Gross: $0.12M
terminal cancer
96. Other People (I) (2016)
Unrated | 97 min | Comedy, Drama
A struggling comedy writer, fresh off a breakup and in the midst of the worst year of his life, returns to Sacramento to care for his dying mother.
Director: Chris Kelly | Stars: Jesse Plemons, Molly Shannon, Bradley Whitford, Maude Apatow
Votes: 12,609 | Gross: $0.09M
cancer
97. The Long Kiss Goodnight (1996)
R | 121 min | Action, Crime, Drama
Samantha Caine lives in a small town with her daughter. Eight years ago she emerged, two months pregnant, from a nearby river with no memory of her past or who she is. However, she's getting closer to finding out about her past.
Director: Renny Harlin | Stars: Geena Davis, Samuel L. Jackson, Yvonne Zima, Craig Bierko
Votes: 85,714 | Gross: $33.33M
Amnesia
98. Mr. Jones (1993)
R | 114 min | Drama, Romance
After being arrested during a manic episode, a man who suffers from bipolar disorder is treated by a psychiatrist who begins to develop romantic feelings towards him.
Directors: Mike Figgis, Jon Amiel | Stars: Richard Gere, Lena Olin, Anne Bancroft, Tom Irwin
Votes: 7,661 | Gross: $8.32M
Bipolar disorder
99. Iris (I) (2001)
R | 91 min | Biography, Drama, Romance
True story of the lifelong romance between novelist Iris Murdoch and her husband John Bayley, from their student days through her battle with Alzheimer's disease.
Director: Richard Eyre | Stars: Judi Dench, Jim Broadbent, Kate Winslet, Hugh Bonneville
Votes: 19,148 | Gross: $1.29M
Alzheimer
100. Hugo Pool (1997)
R | 92 min | Comedy, Romance
An LA pool cleaner/Alyssa Milano falls in love with a young man with ALS/Lou Gehrig's Disease.
Director: Robert Downey Sr. | Stars: Alyssa Milano, Mark Boone Junior, Malcolm McDowell, Brendan Dawson
Votes: 2,097 | Gross: $0.00M
Lou Gerhig's Disease
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