Hulk chases Leader back in time to the Jurassic era, but their actions result in present Earth being taken over by dinosaurs! Hulk battles Leader in the past to save all of time.
While escorting Abomination to stand trial for his crimes, the Hulks run into Ghost Rider, who has come to make both Abomination and Red atone for their past bad deeds.
Hulk follows Leader back in time to the Viking Era and teams up with young Thor and Loki. The Agents of S.M.A.S.H. fight to stop "All Father" Leader from taking over the planet.
Hulk pursues Leader back in time to the Victorian era and unites the Howling Commandos against Dracula, who wants to shroud the Earth with Leader's gamma cloud.
Following the incident caused by the Agents of C.R.A.S.H., the Agents of S.M.A.S.H. get transported to Skaar's home planet Sakaar where they must stop Leader from controlling the entire planet and the Agents of S.M.A.S.H. themselves.