When Sara, a prison nurse, assists in the transfer of convicted murderer George, a vampire descends on Orleans County Penitentiary. Her brother Nick, an ex-cop, ignores the wishes of his former partner, Gina, and sets off to find Sara.
Nick and George's paths cross in the home of a local drug dealer. Nick wants answers, but the three men are surprised by a vampire who has been following George across town.
Nick learns the truth about what's happening to his sister Sara, while on the other side of town, Sara is making the horrifying discovery all for herself.