When a teleporter gets stuck in Melanie's diaper, Krypto and Kevin have to save her before Melanie teleports herself into danger. Streaky feels neglected when Andrea adopts a new cat named Delilah.
Kevin and Krypto have to spend a day in each other's bodies when red kryptonite causes their minds to switch. Krypto becomes Bathound's partner when they chase after Joker's hyenas.
Kevin learns what it's like to be a dog when aliens adopt him as their pet. When dogs all over the city start acting like other animals, Krypto investigates and discovers that Mechanikat is the cause.
When Krypto loses his powers because of red kryptonite, Bathound tries to equip him with bat gear. Krypto is stalked by a companion robot dog from Krypton who is programmed to be his best friend.
Krypto poses as an old firehouse Dalmatian in hopes of helping the aging dog keep his job. Chaos reigns at the zoo when a zookeeper's assistant takes Kevin's communicator and starts doing everything the animals request.
Streaky tries to be a big-time superhero to impress his nephew, Squeaky. A movie star dog makes a pact with Snooky so that the actor can wear a super suit that gives him powers.
When Krypto is captured by Mechanikat, the Dog Stars send in a reluctant Streaky to sneak aboard Mechanikat's ship. Krypto and Kevin are reduced in size by aliens who are collecting specimens from other worlds.
Streaky programs Dogbot to do super deeds so that Krypto can spend more time with Kevin. Kevin's bad boy cousin, Bailey, visits and discovers Krypto's secret.
Bathound has a crisis in confidence when he pursues Catwoman's cat, Isis, who is able to use a bad luck charm against him. Krypto must come to the rescue of the Dog Stars when they are forced to perform in a space circus.
Red kryptonite causes Krypto's tail to detach and take on a life of its own. Krypto, Kevin and Streaky have to save Metropolis when Ignatius changes the weather, turning winter into summer.
When a baby monkey comes into her life, Melanie learns why monkeys are better off in the rainforest and humans are better off at home. When Bathound is affected by laughing gas, he becomes too silly to fight crime.
When Streaky accidentally gets the power of invisibility, it wreaks havoc on his life. The Dog Stars are given chew toys that make them annoy one another.
When Krypto gets amnesia, the Downtown Dogs trick him into thinking he's part of their group. Tail Terrier leaves the Dog Stars for the comfy life of a pet only to discover that it's not all that it's cracked up to be.
Streaky speaks before his fan club and tells a whopper of a tall tale about his superhero exploits. Drooly, a dog who desperately wants to join the Dog Stars, gets his chance when Snooky endangers the Dog Stars.
When Kevin and his class eat Ignatius's lighter-than-air muffins, they start floating away, forcing Krypto to come to the rescue. Krypto and Kevin try to stop Ignatius from going back into the past in order to change the future.
In order to control the Dog Stars, Mechanikat turns them into puppies. Krypto is forced to partner with Ignatius while investigating thefts within Lexcorp.
Krypto and Bathound pursue a villain named Dogwood who steals trees. Krypto and Kevin are at their wits' end when an enlarging ray turns Melanie into a 30-foot giant.
Bathound assists the Dog Stars when Hot Dog goes missing. Krypto comes to Jimmy The Rat's aid when he disguises himself as a dog and becomes a member of the Downtown Dogs.
A royal cat has a "Roman Holiday" with Streaky, allowing Isis the opportunity to steal the Queen's jewels. Krypto becomes jealous when he thinks Kevin likes Bathound more than Superdog.
Bathound is frustrated when a feisty Robin decides to become his crime-fighting partner. Krypto and Streaky have an undersea adventure when red kryptonite turns them into fish.
Kevin learns a lesson about the importance of family when he and Krypto are magically transported to Storybook Land, where the characters resemble Kevin's relatives. Krypto and Kevin's trip to Storybook Land continues.