Jeanette Foley, a lonely dangerous woman, inherits a precious white Pekingese from her eccentric companion along with a large sum of cash to care for the creature. The eccentric's family, however, wants the money and the dog back. So, Jeanette, fleeing from the greedy relatives, goes under cover. She finds herself in South Carolina hiding in a rented Airstream trailer behind the home of Edna Luster, a bitter bible-thumping widow. Edna's son, John, is an out of luck con-artist who is tormented by his opverpowering mother and clausstrophobic home. Puppy Love delves into the lives of John and Jeanette, two misfits- desperate, volatile, lonely, slightly criminal, thrown together under the stormy South Carolina sky.