Darrin Call, a psychotic, suffers a breakdown in a pharmacy in Kentucky and stabs 3 people to death before running off and the BAU are called in to catch him.
While tracking a family annihilator, the BAU must seek advice from "The Fox," one of the most horrific killers from the team's past who has an ominous message for Agent Hotchner.
The relatively new Highway Serial Killer Database reveals an interstate serial killer who abducts then strangles women without sexually assaulting them.
The BAU team travels to San Francisco to investigate the murders of several homeless men and teams up with a separate group of BAU operatives who are working another case they think is connected.
The team, including Garcia, go to the small town of Franklin, Alaska, to catch a rapidly escalating serial killer before the locals take justice into their own hands.