Gypsy and Nick are staying in motel room number 237. That's the same number of the infamous room in The Shining.
Patricia Arquette and Margo Martindale also worked together in Pilot (2005), In Sickness and Adultery (2005) and Blood Relation (2006).
This is largely a flashback episode seeing Dee Dee as a young mother (and with Patricia Arquette appearing more her usual self with less grotesque make-up) and her troubled relationship with her overbearing mother, played by Margo Martindale.