July 23 2022 was the last episode, Showtime canceled the show due to Desus & Mero splitting up over their long time manager Victor Lopez who had allegations of inappropriate behavior. Desus & Mero disagreed on keeping the manager henceforth the split up. The 4th season was canceled before it was finished. Both Desus and Mero both have other projects in the works obviously not together.
Desus & Mero appear without hats on in only one episode.