"Without Me" reached number one on the Billboard Hot 100; subsequently becoming Halsey's first number-one single as a lead artist.
The song reached the top three of eleven other countries, namely Australia, Canada, Hungary, Malaysia, Portugal, Slovakia, Ireland, New Zealand, Singapore, Greece and the United Kingdom.
Halsey performed "Without Me" live on a number of high-profile occasions; she performed it on The Voice, The Ellen DeGeneres Show, Saturday Night Live, at the 2018 MTV Europe Music Awards, at the 2018 Victoria's Secret Fashion Show, at the 2019 iHeartRadio Music Awards, and at the 2019 Billboard Music Awards.
The track was certified quintuple Platinum in the United States and Canada, six-tuple Platinum in Australia and Platinum in the United Kingdom.