The episode title refers to the song Barely Breathing by Duncan Sheik (1996).
Nathan Parsons, Riley Voelkel, and Claudia Black all starred in season 2 of The Originals (2011) together.
This is the first episode with Isobel speaking the opening narration.
While Isobel Evans-Bracken settles into Roswell Community Medical, she mentions being scared of "going all Dark Willow" this is a reference to Buffy the Vampire Slayer. The series is referenced multiple times in this show, likely because it was popular at the same time as the original Roswell.
Claudia Black plays Ann Evans, Max and Isobel's human adoptive mother. She previously portrayed an alien in both Farscape and Stargate SG-1.