The team find out that the active ingredient of the Z biscuits is lithium from batteries. Lithium is also a medication used to treat mental illness, in particular Bi-Polar Disorder/Manic Depression. The lithium has a calming effect on the talkers, in the same way that the medication lithium can stabilise mental ill health.
At about 9:36 Roberta Warren uses the quote "what doesn't kill you, makes you stronger." The quote originates from Nietzshe. In 1888, German philosopher Friedrich Nietzsche first stated, "Out of life's school of war--what doesn't kill me, makes me stronger."
When asked who they are Doc answers "I'm Seigfried and this is my partner Roy (10K)". Seigfried and Roy are a German-American duo of magicians and entertainers.
The episode's title is a play on "state of mind" but modified to reflect where most of the action takes place.