Henry VII briefly considered marrying Catherine of Aragon but instead of giving consent to the match Ferdinand and Isabella rejected it. They still wanted an alliance with England though and thought a better match would be with the future Henry VIII.
In the letter that Queen Isabelle gives Princess Catherine Isabella writes that Catherine's sister Joanna stayed with Isabella when she had a baby. Isabella makes it seem like it was Joanna's choice. It was not. Joanna wanted to back to Flanders and her husband, but Isabella made her stay for over a year before letting Joanna go back.