Producer Matt Nix says the cameo by X-Men creator Stan Lee happened through chance. Lee was in Dallas for a comic convention, which was where shooting was taking place. He was able to shoot his cameo in 20 minutes. Nix said, "That's the kind of thing where I think people sometimes underestimate the degree to which we who make the show are just another group of fanboys trying to make something happen by the skin of our teeth."
When Andy Strucker is first introduced at school, he is sketching a wolf in a notebook. In the comics, Andreas and Andrea Von Strucker are collectively known by the code name Fenris (sometimes Fenris twins). This name is taken from the Fenris wolf from Norse mythology, who is also a separate character in the Marvel Universe and appears in Thor: Ragnarok (2017).
One time X-man Tessa, a.k.a. Sage makes her live action debut in this episode as a member of the secret Mutant Underground.
Amy Acker, appeared in another Marvel franchise "Agent's of Shield". She played Phil Coulson's former girlfriend.
Stan Lee: a customer leaving Tex's Lounge. This his first appearance in an X-Men TV show. When he passes by the sign briefly reads "X's Lounge."