- Sheldon and Amy await big news.
- Sheldon and Amy nervously await the announcement of the Nobel Prize recipients for this year, with Leonard and Penny by their side for moral support. When the Physics prize recipient is announced, Sheldon and Amy react to the news in unexpected ways, but for different reasons. While Amy is able to overcome her negative feelings with a little help from Raj, Sheldon may be a little more difficult a case in consoling. Meanwhile, Leonard, Howard and Bernadette try to take advantage of Sheldon and Amy's new situation, each in a slightly different way. And something different is going on with the apartment building which may further push Sheldon over the edge.—Huggo
- Early in the morning Leonard, Penny and Amy are falling asleep while Sheldon sings about the half-life of radium waiting to hear if they had won the Nobel Prize. Then Sheldon falls asleep. Leonard gets excited because Sheldon had told them to slap him if he did fall asleep. Leonard feels that he's paid enough dues with Sheldon to get the honor. Before he has a chance, the phone wakes Sheldon up. It's only Kripke tricking them into thinking he is the Nobel committee. The phone rings again, but it's only Howard and Bernadette checking in on them. Sheldon suggests that they play a number guessing game, when Amy's phone rings. She quietly answers it, thanks them and then quietly tells everyone that they won. Penny and Leonard get excited. Amy asks if Sheldon believes it, so Sheldon says that he could be dreaming. Leonard slaps him and then Sheldon shouts that they won the Nobel Prize and all four make an excited embrace.
Coming down the stairs, Sheldon and Amy discuss winning as Sheldon gets congratulatory texts from Meemaw, his mother, Missy, George and both of his brother's ex-wives. Amy gets a text from CVS and from her father, who also sends one to Sheldon. Sheldon tells Amy that their names will be linked forever. Amy reminds him that they are already married. Sheldon explains that that is a piece of paper and the Nobel is a piece of paper and a medal. A large group of reporters are waiting for them outside of the building. Sheldon is spooked and runs away. Amy is asked whether Dr. Cooper is returning. She replies no and asks for the next question.
At the Caltech cafeteria, the guys are asking Leonard about how he struck Sheldon. President Siebert joins them and he wants their friends to describe the new superstars of physics as "quirky". Howard jokes that they shouldn't call them "Mr. and Mrs. Wackadoodle." The Coopers enter the cafeteria and are applauded though Sheldon quickly leaves. And the President leads the guys in describing his behavior as "quirky".
Howard walks by Sheldon's office and finds a reporter knocking on his door. Howard looks in and finds Sheldon hiding behind the desk shaking his head now that he doesn't want to see him. Howard tells the reporter Sheldon isn't in and then leads him to the cafeteria to talk and give his perspective as Sheldon's "best friend" and to tell outer space stories.
Raj passes by the ladies' room and hears Amy crying. He checks in on her and she tells him that she looks so terrible in the photos posted on the Internet. Raj calls her a beautiful woman and if she doesn't like it, she can make some changes. New clothes and a new haircut. Amy thinks that that sounds expensive, but Raj reminds her that she is getting a substantial cash prize with the Nobel.
Howard comes into the kitchen asking about dinner. On her computer Bernadette asks about the article on Sheldon that talks more about him instead of his "best friend" Sheldon. Howard reacts that Leonard was more of Sheldon's "monkey butler" rather than his best friend. The reporter also wanted Howard to put him in touch with Amy's best friend. Bernadette says that that is Penny. Howard adds that it doesn't have to be as they smile at each other.
Sheldon and Leonard are having tea together as Sheldon laments all the changes that make him feel distant from reality. Sheldon has wanted a Nobel Prize all his life, but never really thought about the consequences. Raj comes in wanting to show Penny his latest creation, the new and improved Dr. Amy Farrah Fowler. In comes Amy in a classy sleeveless dress and coat wearing larger glasses and a shorter styled haircut looking very happy. Leonard thinks that she looks amazing, but Sheldon prefers the old Amy. Amy looks disappointed as Sheldon runs out with Leonard following. Sheldon explains that Amy was the one thing he could count on that didn't change. Sheldon claims that that is the last straw as the elevator doors open and out walks Penny. "Can you believe it? They finally fixed the elevator!" Sheldon calls it a nightmare and runs down the steps. In the lobby he is surprised as he finds Penny waiting for him. She took the elevator down and she says it is really fast. Sheldon has to be alone, but he doesn't mind Penny providing transportation.
Back in Apartment 4A, Amy says that she should have seen this coming and that she should have changed her hair slowly over ten years. Also she realizes she has had a big day and should be able to enjoy it without worrying about how it affects Sheldon.
Penny is having a drink at the Cheesecake Factory with Sheldon who is complaining about all the changes which include Amy. Penny is drinking every time Sheldon uses the word "change". Penny then tells him that he's the only person in the world who could win a Nobel Prize and still be upset about it. She reminds him how much he has changed having friends, being married, living in a new apartment, wearing a baseball cap and having had sex almost as many times as Penny has fingers. Actually he's had it two more times than that number.
Sheldon adds that Penny is also married with a successful career and she no longer dresses like she is trying to attract sailors on the wharf. Penny concludes that since changes keep occurring, then the fact that things change is a constant. Sheldon interprets that as that the inevitability of change might be a universal constant. Then, on the television they see Howard and Bernadette talking about the Coopers and she is claiming to be Amy's best friend. Penny goes back to drinking.
Still back in Apartment 4A, Amy likes how her hair looks. All of them are going to stop tip-toeing around Sheldon just so he won't get upset. They feel like they were being enablers. Leonard mentions both Sheldon's Spot and controlling the thermostat setting as examples. He is always cold and that is why he keeps wearing hoodies. Then Leonard mentions the DNA model that has been there since Leonard moved into the apartment, which Sheldon forbade anyone to touch. Amy suggests that he put it in the closet. Leonard agrees, but as he tries to move it, hundreds of balls (atoms) fall off of it.
Penny and Sheldon enter the lobby as Sheldon heads up the stairs. Penny asks Sheldon if he wants to try the elevator. Sheldon mentions that it did work when he moved into the building. The repaired elevator is a return to the status Quo. Penny just pushes him into the elevator. She smiles not having to walk up and Sheldon calls the ride "wild".
Title reference: Penny pointing out to Sheldon that the only constant in life is change.
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