The visit to Ghana helped secure funding for the Volta Dam from the USA instead of the Soviets, reducing their influence in Ghana. Once the Queen returned, Prime Minister Macmillan contacted President Kennedy to say, "I have risked my Queen. You must risk your money."
Jackie Kennedy speaks of Dr. Jacobson and his cocktail of vitamins. Dr. Max Jacobson was a physician known as "Dr Feelgood". He administered amphetamines as part of his "vitamin cocktail" injections. Many of his clients were high profile celebrities, including John F. Kennedy. The death of presidential photographer Mark Shaw led to the discovery of Dr. Jacobson's use, and abuse, of drugs on his patients. His medical license was revoked in 1975.
The episode won an Emmy Award for Outstanding Period Costumes.
When the Queen and Mrs. Kennedy meet at Windsor, the Queen serves a cream tea, a traditional speciality of Devon and Cornwall which consists of tea served with scones, clotted cream, and jam. In the scene, the Queen prepares her scone via the Devonshire method, which is to split the scone in two, cover each half with clotted cream, and then add strawberry jam on top. The Cornish method is basically the opposite: split the scone, spread it with strawberry jam, and then top it with a spoonful of clotted cream. The Cornish method is commonly used elsewhere, notably in London.
Julian Ovenden, who plays Bobby Kennedy, had earlier played JFK in Smash (2012), a TV show about the making of a musical about Marilyn Monroe that includes JFK's affair with her.