The part of the Simms' house was played by "La Belle Maison" at 30 Fifeshire Rd. in Toronto. The mansion, built in 2013, is 24,000 square feet with 12 bedrooms.
The concept of the pathogen released in the fog closely resembles "Ice Nine" from Kurt Vonnegut's 1963 novel Cat's Cradle.
This episode shares its title with a 2000 movie starring Ben Stiller and Robert De Niro.
Luke Macfarlane (D'avin) and Marco Grazzini (Hank) both starred in Hallmark's "A Valentine's Match".