This episode marks the return of Colton Haynes and Charlie Carver. Haynes last appeared at the end of Season 2 episode "Master Plan" and Carver last appeared at the end of Season 3 episode "The Divine Move".
The episode is also a reference to John Landis' 1981 film An American Werewolf in London which was last mentioned at the begining of Season 3 after Jackson Whittemore (Colton Haynes) moved to London.
The episode Werewolfs of London shares the same name as a song by Warren Zevon from 1978.