Lip's plan for staying sober involves trading his AA chips for drinks, and he traded three for a shot, a beer, and a boilermaker. Lip was only in rehab for 30 days, so he should only have two chips, the 24-hour and the 30-day, not the stack of chips he has.
Frank wakes up after 29 days in a coma and can't use his legs because his muscles have atrophied. His arms seem to be working just fine and his arm muscles have not atrophied.
Debbie buys a Diaper Genie but the shipping label on the box indicates a delivery address in California.
Frank could not have ended up Lak Michigan as the course of the Chicago River was reversed in the very early 20th century so that it flows away from Lake Michigan.
Only 30 days have passed between seasons 6 and 7, and Frannie was only weeks old at the end of season 6, while in this episode she looks to be more like six months. Also, the baby actresses who play Frannie in this episode don't even look alike.