"Grampa" Abe Simpson reveals that he is 86. However he also refers to Canadian Prime Minister Trudeau. Grampa was, therefore, born in 1930, and would be 15 or 16 on V-E Day in 1945. This makes it impossible for Grampa to be a World War II veteran--a part of Grampa's story since the beginning of the series.
As the pilot-in-command Isabella would be sitting in the left seat, not the right.
An older airplane requires a flight engineer. Isabella would not be able to fly the plane by herself.
Seat belts in an airplane's cockpit come from behind, not like the seat belt in a car.