When they zoom out on the board with Arizona's rent add you can see an advert for giving away Doc. Meredith's dog from season 2 and 3. The poster says "Playful, Protective Puppy Needs Loving Home... Available Immediately Page Izzie"
This episode introduced Meredith with shorter hair. Ellen Pompeo revealed in an interview that it had to be cut as it was all fried, since she went from darker hair last season to lighter hair this season.
Jessica Capshaw was pregnant with her fourth during season 12 and gave birth shortly after filming ended.