The first WrestleMania where every single champion from the previous WrestleMania was out with an injury.
Due to creative differences between Vince McMahon and Paul Levesque (Triple H), there has been no official order of matches announced as of 29th March 2016, less than a week before the event. According to reports, Vince has been firmly backing Shane McMahon vs The Undertaker as the main event match which will end the show, due to his heavy involvement in that storyline and the stipulations surrounding the match. However, Triple H has made it clear that he would prefer his WWE World Heavyweight Championship match against Roman Reigns to be the main event and to close the show.
Sasha Banks' attire was inspired by Eddie Guerrero's attire he wore at WWE No Way Out (2004) in which she was in attendance. This was also the night she decided she wanted to become a professional wrestler. In a podcast interview, Chavo Chavo Guerrero Jr. criticized Sasha's "tribute" to Eddie, because WWE did not contact Chavo to be a part of the event.
Charlotte's robe was made from pieces of her father's (Ric Flair) robe that he wore to the ring for his retirement match at WrestleMania XXIV (2008).
Titus O'Neil missed out on the chance to appear at this event, as he was suspended from the company for 60 days, for grabbing Vince McMahon's arm in an unscripted manner during Daniel Bryan's retirement speech segment at the end of the February 8, 2016 edition of RAW.