This episode revealed that Milhouse's parents are also cousins. This had been speculated by fans since the beginning of the series as his mother and father share many similar features.
Milhouse's cousin Annika is voiced by a real van Houten, Carice van Houten.
Homer recites a long list of what he calls movies about a dystopian future: The Hunger Games (2012), Edge of Tomorrow (2014), Oblivion (2013), Elysium (2013), Snowpiercer (2013), The Hunger Games: Catching Fire (2013), X-Men: Days of Future Past (2014), Ender's Game (2013), The Road (2009), World War Z (2013), Children of Men (2006), After Earth (2013), I Am Legend (2007), Mad Max: Fury Road (2015), The Maze Runner (2014), District 9 (2009), The Purge (2018), Looper (2012), Cloud Atlas (2012), Divergent (2014), The Divergent Series: Insurgent (2015), The Island (2005), Mr. Burns, a Post-Electric Play, and Chappie (2015). All of these are indeed movies about post-apocalyptic or otherwise extremely pessimistic visions of the future--with the notable exception of "Mr. Burns, a Post-Electric Play," which as of 2020 has not yet been made into a film. Instead, it is an experimental 2012 stage play by Anne Washburn that imagines a world after an unnamed cataclysm in which the world's survivors rebuild their society and culture around reenacting old episodes of The Simpsons.
The title is a reference to "Let's go fly a kite".
This a rare Simpsons episode to discuss vaping.