Yasuhiro Nightow originally started out the story as a a vampire hunting story in a contemporary city. The final product turned out more humorous and fantastic, distinctly influenced by Nightow's Trigun (1998) series.
The team of heroes is named Libra. Libra is Latin for "weighing scales", which represents maintaining balance and order.
The Black and White storyline is a series-only story that does not appear in the manga comic.
Shinji Ogawa was originally cast as Gilbert F. Altstein, but due to poor health he had to back out and was replaced with Banjô Ginga.
Episodes 1 and 2 were previewed at a screening at Odaiba Cinema Mediage in Tokyo on March 21, 2015. Regular broadcasting began on April 5, 2015. The final episode was originally scheduled to broadcast on July 4, 2015, but was delayed to October 4, 2015.