Leonardo Watch visits Jerusalem's Lot with a certain purpose. He is taken to Libra; a secret society of super-humans, as a different person. Soon after that, Femto starts a horrible game in the city.
When Leonardo saw one station wagon of the laundry, at a glance he noticed the contents of the baggage. Zapp was with Leonardo, he'd hurried to contact Libra.
"Angel Scale", the name of a strong psychoactive drug brought in from netherworld, and it begin to flow out of Jerusalem's Lot. Klaus takes the problem seriously, he goes to a big-shot of netherworld to demand information.
In the subway, Leonardo found a person having the wing which shined red. Klaus was surprised to hear it, he call in his mentor; a vampire hunter, Blitz T. Abrams.
Aligura also known as "Queen of Monomania" drives a huge monster-truck recklessly toward Pandorum Asylum; a prison for super-human criminals. She wants to meet her beloved man in there.
Although Zapp and Zed are fellow pupils, they don't always agree. Leonardo asks them to go out for lunch because he wants to support any friendly relations between them.
The mixed twins was born in Macbeth family which has PSI; supernatural power. White, the little twin sister can't use her power at all. On the other hand, Black, the elder twin brother has very strong power. The past of twins is revealed in the end.
"King of Despair" tries to break down the barrier between the netherworld and Jerusalem's Lot by using Leonardo's "All Seeing Eyes of God". Libra and LHOS work closely together to find Leonardo and Macbeth twins.