"King of Despair" tries to break down the barrier between the netherworld and Jerusalem's Lot by using Leonardo's "All Seeing Eyes of God". Libra and LHOS work closely together to find Leonardo and Macbeth twins.
In the subway, Leonardo found a person having the wing which shined red. Klaus was surprised to hear it, he call in his mentor; a vampire hunter, Blitz T. Abrams.
Leonardo Watch visits Jerusalem's Lot with a certain purpose. He is taken to Libra; a secret society of super-humans, as a different person. Soon after that, Femto starts a horrible game in the city.
The mixed twins was born in Macbeth family which has PSI; supernatural power. White, the little twin sister can't use her power at all. On the other hand, Black, the elder twin brother has very strong power. The past of twins is revealed in the end.