The tape that Mrs Simian plays is Beethoven's Moonlight Sonata.
Tobias can be seen among the infected when Simian is locked in her office. This shows that he was eventually infected, or possibly was faking it.
The fourth wall is broken four times. The first time is when the camera hits Miss Simian's face. The second time is when the time-stamp knocks Miss Simian over. The third time is when she drags the time-stamp away. The fourth time is when the rainbow-liquid from an infected Gumball and Darwin splatter on the camera as they infect Principal Brown.
According to the security cameras, it takes place on January 16th, 2014.
In the last scenes Tina appears in, her eyes are strangely demonic.