I've probably seen this a hundred times, it never gets less funny. Every aspect seems unplanned and the genuine reactions from both the actors and actresses makes me laugh every time.
The Anderson Cooper joke is one of the most brilliantly delivered lines I've ever seen, and the only thing that would make the whole thing better is seeing an uncut version.
The only part I found disappointing is the actor, Derek apparently not wanting to say his lines, though it's unclear if this was scripted, or because something had happened which made him uncomfortable with the entire sketch.
Overall, a 10/10 watch, with infinite rewatch value.