This film marks Lindsay Lohan's first theatrically released leading role (with a wide release) in 18 years. Her last such film was I Know Who Killed Me (2007).
Jamie Lee Curtis (Tess), Lindsay Lohan (Anna), Chad Michael Murray (Jake), Mark Harmon (Ryan), Stephen Tobolowsky (Mr. Bates), Rosalind Chao (Pei-Pei), Lucille Soong (Pei-Pei's mom), Christina Vidal (Maddie), and Haley Hudson (Peg) are all reprising their roles from the previous 2003 film.
This will be the first Freaky Friday movie to be shot in a widescreen 2.39:1 aspect ratio, unlike Freaky Friday (1976), which was shot in a taller 1.85:1 aspect ratio.
Lindsay Lohan and Elaine Hendrix reunited since the Movie they Did together from Walt Disney Pictures in (1998) The Parent Trap.