This is the fourth film Vito Trigo has appeared in as a major character that also involves Lloyd Kaufman. Except for Science Team, Trigo also starred in Mr. Bricks, which was produced by Kaufman and has a cameo by him and appeared in Return to Nuke 'Em High Volume 1 and 2 in which Lloyd directed and wrote.
Actor and stand up comedian Josh Potter improvises a line about Jeff Dunham that almost ended up on the cutting room floor.
Though edited from the final cut, lines of dialog in the script referred to the novel that Chip is writing as a "massive work of speculative fiction".
The crazy cop character Dueger Tenowon Smith was named after a bar in Niagra Falls, NY called Dueger's Tenowon Grill. Many members of the Science Team crew also worked on the Troma film Return to Nuke 'em High and would go to the bar nightly while living in a nearby abandoned funeral home.
Vito Trigo did all of his own stunts and actually ran barefoot through the forest for the entirety of the woods chase sequence.