The St. Agnes orphanage Skye refers to growing up in is the same one Foggy Nelson mentions in Daredevil (2015).
In the comics, Doctor Franklin Hall is also known as Graviton, a very powerful Super Villain who has physical control over the forces of gravity.
According to Quinn's presentation Gravitonium's atomic number is 123, and its atomic mass is 308. Both these numbers are higher than anything on the Periodic Table in reality.
The title appears to reflect the intelligence community definition of an 'asset' as well as the proprietorial approach S.H.I.E.L.D. takes to Dr. Hall.