Stewie says to Meg, "Oh my god, we're getting closer to the beginning. You're Lacey Chabert!" This is in reference to Chabert playing the voice of Meg for the first two seasons of the show before Mila Kunis.
This is the 200th episode of Family Guy.
The plot of the film hinges on time moving in reverse. The episode title, "Yug Ylimaf" is the name of the show reversed.
Road To Germany was infamous for being the first time a character on Family Guy used the word "cunt" (in the uncensored version). In this episode Stewie can be heard saying it again, but only in a scene that was deleted.