Khione appears to have powers related to life, based on the facts that she revitalized Mark and sensed the baby in Iris.
The new Rogues saying it's the normal craziness for a Wednesday reflects the fact that the show premieres on Wednesdays.
Iris states she was supposed to become pregnant in three more months, placing this episode in February 2023.
Joe, Cecile, and Jenna are moving to the country, leaving the West house to Barry and Iris, because Joe feels there's no more need to be in Central City, having done his part in raising its heroes and working as a cop. This is consistent with the future seen in Negative, Part One (2022) in which Nora and Bart inherit the Barry and Iris's apartment by the 2040s.