During production, Sarah Gadon and Caleb Landry Jones both decided not to meet or rehearse prior to the filming of the hotel room scene where Syd takes a sample of Hannah Geist's blood. They both felt it would help preserve the separation of the characters within the story.
All of the close-up shots of needles entering skin in the film are real.
Almost half of the content of the film was shot during pre-production. This includes the vast amount of playback footage and the many stills needed to decorate the sets and to be used with props.
Feeling the movie had very limited commercial value, the Canadian and American distributors only gave the movie a very limited release, resulting in the movie becoming a failure at the box office.