When Dean sees the betting record with future information, he remarks "He's using the Biff strategy!" This refers to Biff Tannen from Back to the Future Part II (1989) who uses 21st century sports almanac to place winning bets on horse races in 1955.
Chronos/Chronus is a deity in Greek mythology, a personification of time. He is at times identified with the similarly named Titan, Kronos/Cronus, the God of the Harvest.
Nicholas Lea, who plays Eliot Ness was an important character in The X-Files (1993). Many other actors from Supernatural, including Mitch Pileggi (Samuel Campbell) previously starred on that show.
Episode references Kevin Costner's 'The Untouchables' and also features some of the music from the 1987 movie.
Seventh episode to not feature the Impala. Sixth episode in a row to not feature it.