It was revealed at Comic Con that actual descendants of the Brothers Grimm reside in Portland. The producers had no idea until a member in the audience told them.
Whenever the episode includes a room number (hotel room, hospital ward or bed) or address, the number is the combination of the number of the season and of the episode. For example, the hotel room of Adalind was shown first in episode 12 of season 2, and the room no. was 212.
David Giuntoli and Bitsie Tulloch grew to love Portland so much, they relocated out of L.A. and stayed in the Pacific Northwest, even after the series ended.
David Giuntoli (Nick) and Elizabeth Tulloch (Juliette/Eve) announced their engagement at Comic-Con in San Diego.
The exterior of the police station is the Custom House located in the Pearl District of Portland