Bret Hart's first WrestleMania appearance in 13 years; he was inducted into the Hall of Fame 4 years earlier but did not actually attend the event
Triple H's first WrestleMania match that wasn't for a world championship since his match against the Undertaker at WrestleMania 17.
CM Punk's first singles match at WrestleMania and the first time that he did not compete in the Money in the Bank ladder match.
R-Truth, Cody Rhodes, Jack Swagger, Dolph Ziggler, Drew McIntyre and Sheamus first WrestleMania Match. With Cody's debut every member of the Rhodes family has competed at WrestleMania. The Miz had competed at The 25th Anniversary of WrestleMania (2009), but only in a dark match.
Ted DiBiase, Evan Bourne (Although the two would compete in the pre show battle royal, at WrestleMania 27), and Vickie Guerrero's only WrestleMania Match.