The actress who plays Ellen, Andrea Friedman, also has Down Syndrome.
This is the first episode in which Chris and Meg understand Stewie.
One of the ongoing jokes of the series is that Bruce's lover, Jeffrey, is often heard speaking, but never appears on screen - which continues here in the scene where Bruce finds Chris and Stewie.
This is the first (and to date, the only) episode in which Meg farts.
Carter suggests they get "Medium" to help find Chris and Stewie. Lois says that's not a real person, just a character on a show, but the lead character of 'Medium' is, in fact, based on a real person, Allison DuBois.