There is a common misconception among fans that the game is supposed to be a prequel to the original The Transformers (1984) television show. This is false. Hasbro, the toy company behind Transformers stated the game is a prequel to the Transformers Prime (2010) TV show, although in an interview with voice actor Peter Cullen, he seemed to have denied this. Some say War for Cybertron is in-continuity with whatever Transformers universe any given person thinks.
The first full official trailer for the game marked the first time that Optimus Prime's famous quote ("One shall stand, one shall fall") was finished by his arch nemesis, Megatron.
This is the third time Peter Cullen is reprising his role as Optimus Prime, just like he did in Transformers G1 and in the live action Transformers movies.
This is the third time in Transformers history for Optimus Prime to use any kind of ax since Transformers G1 and Transformers Animated.
Megatron's original voice actor, Frank Welker was auditioned for the role, but his voice didn't fit this interpretation of the character.