Luke travels to Egypt in search for some black cumin to give to Jean, but instead finds Tang who had Tutangkamen's Mask in his hand. Luke catches Tang, but the two are together framed to be thieves and are chased by the Medjay.
Luke escapes from his prison cell to return to the Stars hotel. But he soon realizes that Tang was innocent and that history has changed, so he heads back to Egypt to save his old buddy.
Luke saves Tang and catches the real thief of Tutangkamen's Mask, but learns that he too was ordered by someone else. Luke heads back to the present to decipher the code encrypted on a mirror in pursuit of the true culprit.
Luke finds out that the true culprit headed to the Abu Simbel Temples and heads that way. In the end of the mysterious labyrinth Luke finally meets the Relic Hunter Indiana, but he seems to recognize Luke..
Indiana uses Tutangkamen's Mask as a key to open the inner doors of Abu Simbel Temple in attempt to take the hidden sword of Ramses the 2nd. Luke engages in a battle to protect the sword and realize his destiny.
The young lady of Pompei, Mia runs with the Statue of the Faun in her hands. Luke and Jean land in Pompei and chase Mia into the underground waterways and catch the little thief. But out of nowhere, Indiana shows up.
Mia escapes while Luke and Indiana are busy in battle, but loses the statue to some thieves. Luke and Jean team up with Mia to retrieve the statue, but it is already sold as a prize to be given to the Coliseum's greatest gladiator.
Luke battles to win the greatest gladiator's prize : The Statue of the Faun. But his foe is Indiana. The dust settles with our heroes claiming the statue, but the volcanoes of Pompei erupt, putting Mia and her family in danger.
Luke repeats his time travels in attempt to save Mia from her destiny. But things never go right and Luke just makes things worse, with the Statue of the Faun ending up in Indiana's hand.
The doll hidden inside the Statue of the Faun was a token of Mia's father's love, but if Mia were to find out, she would go back into her burning house. Luke has to make his final decision.
Luke travels to Peru and learns of a witch in pursuit of the sacred water. Thinking that the water is the relic to protect, Luke follows her trails to find the condor-controlling Accla, Laura.
After battling Laura and her condor, Luke finds out Laura is actually looking for the sacred water to save her sick villagers. Agreeing to help, Luke travels to a distant jungle only to be met by man-eater plants and huge anacondas.
Luke arrives at Machu Picchu in his quest to find the sacred water, but its citizens lock him up as Laura sacrifices herself in exchange of the water. To make things worse, Indiana makes his appearance to claim the water for his own.
Luke protects the sacred water, but something isn't right. Indiana was actually after the Tumi instead. Luke returns to Peru to save Laura and the relic, but is greeted by the Black Elevator, possessed by a voice of the man behind it all.
Luke and Indiana battle on the peaks of Machu Picchu, where Indiana's comrades Shadowman and Angelina make their appearance. The Relic Hunters put the Relic Guardians in danger and the Tumi is as good as lost, but.
Luke puts together the gifts from his historical friends to reveal a message from scientist Isaac Newton to his grandpa Paul. Luke travels back in time to meet Newton, but Newton's mind is only on Marty who stole his Newtonian Telescope.
Indiana stops Luke from chasing Marty, and Newton can't figure out where Paul is. Luke dives deep into the sea to find of a clue to where Marty went and to stop him from forging the Philosopher's Stone.
Luke finds a clue that pinpoints Marty's location to Stone Henge. But Luke arrives a bit too late as Indiana and his fellow Relic Hunters are already in the middle of the forging of the Stone.
Luke travels through the hidden paths under Stone Henge to find and stop Marty, but the Philosopher's Stone is already complete. Luke pursuits Indiana who took the Stone, but the elevator ends up crash landing.
The elevator ends up in Korea's Jongmyo and the 1800's Big Ben, where the battle between the Guardians and the Hunter commences. Luke retrieves the Philosopher's Stone, but its dangerous powers begin to come back to light.
Indiana kidnaps the young technician Mei in order to find the Sword of Goujian. Luke meets up with LingLing and heads to Huiji Mountain. Meanwhile at the hotel, Jean is captured by a thug who seems to know the secrets of time travel.
Jean is saved by hotel guest Alan. Meanwhile Luke defeats Angelina and Shadowman to arrive at the top of Huiji Mountain, but there is nothing there to help them find Mei.
Luke finds the Sword of Goujian hidden beneath the Great Wall of China, and encounters Indiana. But Indiana holds Mei as hostage and tushes in to take the Sword of Goujian
Luke fails to save Mei. But he soon realizes Indiana's true destination : The Mausoleum of Qin Shi Huang which holds the Heirloom Seal of the Realm. Luke heads toward the mausoleum but there are dangerous traps waiting for him.
Jean sees that the Reliquary of Pepin is in danger and takes off by herself, Luke following after. But Jean is caught by the English Soldiers and Luke finds himself on a 3 way fork of Jean, Jeanne D'arc, and Indiana.
The Reliquary of Pepin falls in Indiana's hands. Luke realizes that Indiana is headed to Notre-Dame de Paris to open the reliquary and take the Globus Cruciger hidden inside. Luke chases to stop Indiana's plans.
Luke and Jeanne are framed as thieves, but they show their wisdom and heart to Charles VII who gives them another chance. Indiana betrays Mr. X and runs with the Globus Cruciger, Jean chases him down.
With Alan's help, Luke saves the hotel from the time bomb, making the two close friends. Luke then figures out using a radio set on top of Eiffel Tower that Indiana betrayed Mr. X and is heading to Mont Saint Michele.
A three way fight between the Guardians and the Hunters erupts over the Globus Cruciger. Luke seems to retrieve the relic and return it to Jeanne, but at the last second Indiana attacks Luke as he is about to get on his elevator.
Luke searches all over the world for Jean, ending up in Cambodia in order to save the 'Seed of Life'. He meets Sombor who suspects Jean as a Relic Hunter. Even Newton from England points at Jean as the thief of his Newtonian Telescope.
Jean saves Indiana and leaves. With Gottlieb's help, Luke chases Jean to Kotakinabalu Beach, but Jean refuses to return as she had a job to do as the Relic Hunter. Furious, Luke jumps into battle to stop his closest friend.
Luke fights Jean but in the end loses and lets her escape. On top of that, a hostage incident happens in the Starz Hotel, hurting Gottlieb. But with Alan's help the incident is solved and Luke travels to Cambodia in pursuit of Jean.
Luke fights Jean but in the end loses and lets her escape. On top of that, a hostage incident happens in the Stars Hotel, hurting Gottlieb. But with Alan's help, the incident is solved and Luke travels to Cambodia in pursuit of Jean.
Luke learns that Jean and Indiana were gathering the relics to lure in Mr. X and destroy the Black Elevator. Joining forces, the three heavily damage the Black Elevator, but Jean and Indiana lose all the relics.
One of the hotel's maids, Jessica turns out to be a prime suspect to be Mr. X. Luke follows her to Russia and meets up with princess Maria, and learns from her that Angelina and Shadowman had appeared in Russia to steal Czar's crown.
After a battle with Shadowman and Angelina, Luke captures Jessica only to learn she isn't actually Mr. X. Luke decides to pursuit Shadowman and Angelina while Jean remains in the Starz Hotel to figure out Mr. X's true identity.
Luke falls in a trap that locks him and Princess Maria in an ice storage. Meanwhile Jean is attacked by the hotel door man Jackson during her investigations. Coming out of their dangers, Luke and Jean interrogate Jackson.
Luke finds out that there's a hidden message in Gottlieb's letter to Jackson. Luke heads to Bolshoi Theatre, where with the help of Princess Maria he deciphers the hidden code. But the hidden message reveals Mr. X's shocking identity.
Luke returns to the hotel only to immediately be attacked by Alan, who is plotting to go even further to steal the Golden Peacock Clock from Saint Basil's Cathedral. Luke heads to Russia to foil Alan's evil schemes.
Luke finds that Astrolabe pieces are attached to Akbar the Great's shield and heads to India's Ajanta caves. But Angelina, Shadowman, and the blacksmith boy Rahul appear to take the shield for themselves.
Luke loses the shield, but decides to find the swords of Akbar the Great, expecting them to lead him to the shield. Luke heads to Chand Baori and solves the secrets of the stairwell.
After handing over the sword of Akbar the Great to Shadowman, Luke heads to Akbar the Great's tomb to save Sanjay. Luke successfully saves Sanjay with the help of Sanjay, who tells him the location of final sword of Akbar the Great.
Indiana faces Alan, but loses the final sword to his butler Jeff. Luke, despite his anger against Indiana, decides to save him. Indiana tells Luke of a way to defeat Alan, and the two join forces to ambush Alan in an alley's peak.
Luke heads to Greece in search of the final Astrolabe piece, but only finds the little philosopher Theo who won't let him alone. On top of that, Luke learns that not only the relics, but also his friends are disappearing from history.
Luke arrives in Acropolis in search of his friends, but ends up captured by Alan. Alan holds Luke's friends as hostage and tells Luke of his 'New Eden', which erases history as he knows it to replace it with Acropolis in the sky.
Luke and friends commence their operation and save those who had been kept hostage by Alan. But in the last critical moment, the escape airship crash lands, and Alan drops countless henchmen to attack Luke and his friends.