At one point, House comments, "I feel like Mike Tomlin," then says to Foreman, "Maybe not as much as you do." Pittsburgh Steelers' coach Mike Tomlin is often said to bear a striking resemblance to Omar Epps.
The theory mentioned by the patient, that dextromethorphan (DXM) will not harm the brain if taken with a shot of alcohol, is a myth.
When the owner of the bookshop flips over the book, you see a photo of Jonathan Brandis on the back cover.