Fortune City is geographically incorrect. Yucatan Casino is a level above the Platinum Strip, but is also on the same level as the Palisades and the Food Court, but the Food Court and the Palisades are on the same level as the Platinum Strip. Similarly, despite being lower than the Slot Ranch Casino, the Royal Flush is also on the same level as it. Also, the entrance to the Atlantica rooftop and the actual Atlantica rooftop are a distance away.
One of the main psychopaths in the game, Slappy, actually has a face modeled underneath his mask.
A set of Knight Armor, referencing Capcom's Ghosts and Goblins, is available in the game. Equipping it reduces incoming damage but too much damage will cause it to break, leaving Chuck in his underwear.
In Dead Rising 2, the Dodge Roll animation can be canceled. This is only done when you have an item in your inventory that is light. During the animation of the Dodge Roll, press Up on the D-Pad twice and, if done right, Chuck will magically stand erect from just canceling the Dodge Roll, mid-roll. This glitch was fixed in Dead Rising 2: Off the Record.