Missy rips Sheldon's autographed picture of Professor Proton in this episode. Sheldon tapes it back together, but the rip can still clearly be seen. In season six, episode twenty-two of The Big Bang Theory, Sheldon shows the same picture to Professor Proton. But, the rip cannot be seen. Since Young Sheldon takes place while Sheldon is a child and The Big Bang Theory takes place when Sheldon is an adult, the rip should have been seen in the picture in the episode of The Big Bang Theory. But, the show Young Sheldon did not yet exist when that episode of The Big Bang Theory aired.
While working the Jumble and looking at "onpti", Peg asks if nipto is a word and then decides the answer is "pinto". However, the correct word could be "point". She wouldn't know which it is until she tried to write the cartoon's caption and whether she needed an I or an O (whatever the second letter of the correct word is.)