At one point had a working subtitle "Clock Blocked" that was changed for its mature reference. This happened again later when Ratchet and Clank: Four Play was changed to All 4 One.
When fired, the RYNO V plays a five second loop from Tchaikovsky's 1812 Overture.
This is the second game in the series to feature Dr.Nefarious as a main villain.
Alister Azimuth was developed to introduce another Lombax to the franchise, and was considered to be who Ratchet could have become if he didn't have Clank as the voice of reason.
The game was released the exact same year Michael Jackson passed away. His Thriller and Moonwalk dances were recreated by Dr. Nefarious and Alister Azimuth respectively if the Groovitron was used.