Netflix's official release was signed by character Celina Ferrer, described as the principal of Elite Way School. This indicated that the series is an in-universe sequel to Rebelde (2004), wherein Estefania Villarreal portrayed Celina.
Emilia's (Giovanna Grigio) hairstyle pays homage to Mexican pop singer and actress Thalia, who sported a similar look in the 90s.
Numerous cast members of the original Argentine series Rebelde Way (2002) (including its four protagonists) were former Chiquititas (1995) young actors. The Brazilian version Rebel Rio! (2011) had Carla Diaz from Chiquititas Brasil (1997). This new version has Giovanna Grigio, who starred in Chiquititas (2013).
Non of the original Mexican main cast from Televisa wanted to be part of the series.