In the year 2032, aliens have invaded Earth. Humanity bands together and fights back valiantly, but they are simply no match for the invading force, and their numbers steadily dwindle as fighting continues. At the brink of extinction after years of war, one last hope for humanity appears: Black Rock Shooter, a young girl who is also the most powerful biological weapon ever created. Working together with the last remnants of the human race, will she be able to repel the alien invasion and save the Earth?