Susan talks to her former employer, Bob about being fired by him. He then refers to his wife. Susan says: "oh how is Twyla?" Twyla was the name of the character Sarah Levy (Susan) played on Schitt's Creek.
When Susan tells Bob that she saw his wife Twyla with a huge fur made from puppies, she's calling Twyla 'Cruella deVille' from "One Hundred and One Dalmatians".