Paintings that appear in the background of Moe's song are: The Starry Night, Olive Orchard, The Factories at Asnières, The Potato Eaters, Bedroom in Arles, Farmhouse in Provence, Bulb Fields, Olive Picking, First Steps and Fishing in Spring.
Little Caesar, the mascot for the Little Caesars restaurant chain, appears in Florence, Italy. The Noid, the former mascot for Domino's Pizza, then stabs Little Caesar, causing Little Caesar to say "Et tu, Noidus?", which is a reference to Shakespeare's "Julius Caesar".
The scene in the art class is based on true events. Da Vinci was hired by established artist Voracchio to paint a single cherub and, upon seeing his apprentice's work, he broke his brushes and never painted again.
Other students in Verrocchio's class are: Barticelli, a reference to Sandro Botticelli, Dolphatello, a reference to Donatello, and Ralphael, a reference to Raphael.
This is the first episode where Hank Azaria does not play Bumblebee Man as he stepped down from the role. Eric Lopez took over the role and will voice Bumblebee Man from this episode onward.