It's revealed that Lexie is 24 years old.
Guest-star Tyne Daly's brother Tim Daly is cast-member of the Grey's Anatomy (2005) spin-off Private Practice (2007).
The lengthening procedure done on Callie's patient is called the ilzarof leg lengthening procedure. It is commonly performed on trauma patients or those with congenital abnormalities of the limb(s).
This episode shares its name with an episode of the CW show Supernatural (2005). Jeffrey Dean Morgan, who appears as Denny Duquette in this episode, plays a leading role in "Supernatural".
Every episode of the show is named after a famous song. "Sympathy for the Devil" is a song by The Rolling Stones.