Director Anwar Jamison took on the role of Adrian only three days before they began filming the movie. The actor who was supposed to play the role suddenly became scared to travel to Africa at the last minute.
Coming to Africa is Khalil Kain's second movie filmed in Memphis. He starred in the 2015 short film, Arkabutla, the directorial debut of P-Valley show runner Katori Hall.
When Conan O'Brien visited Ghana to film his "Conan Without Borders" travel special in 2019, he appeared on Nana Ama McBrown's #1 rated show, McBrown's Kitchen, only a month before she filmed Coming to Africa.