- A genetically created Anaconda, cut in half, regenerates itself into two aggressive giant snakes, due to the Blood Orchid.
- Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdoch's true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness. Amanda is forced to secretly bring together another team of scientists whom face off against a heavily armed squad of Murdoch's men to steal the coveted orchids before the killer Anaconda hunts both parties down.—matt-282
- In a desperate attempt to cling to life, shortly after the terrifying events of Anaconda 3: Offspring (2008), Murdoch enlists the help of a young doctor to harvest the rejuvenating serum of the rare Blood Orchids. Once more, a failed experiment leads to a new reptilian horror, as an ever-growing, genetically enhanced super-serpent breaks free from the laboratory. Now, the dauntless herpetologist, Amanda Hayes, and a handful of scientists must outsmart Murdoch's armed-to-the-teeth henchmen, to have a fighting chance. But, can they put an end to the nightmare of the mutated Anacondas?—Nick Riganas
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By what name was Anacondas: Trail of Blood (2009) officially released in Canada in English?
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